The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression. In this regard, the ncRNAs possible regulatory role in DDR via modulation of key components expression and controlling repair signaling pathway activation is validated. Therefore, in this article, we will discuss the latest developments of ncRNAs contribution in different aspects of DNA repair through regulation of ATM-ATR, P53, and other regulatory signaling pathways.

DNA 损伤反应 (DDR) 通路的主要目的是维持基因组结构的完整性和稳定性。为了了解非编码 RNA（如 lncRNA、miRNA 和 circRNA）在不同细胞和基因组过程以及癌症进展中的确切分子机制，已经做了大量工作。在这方面，ncRNAs 可能通过调节关键成分表达和控制修复信号通路激活在 DDR 中发挥调节作用。因此，在本文中，我们将通过调控 ATM-ATR、P53 和其他调控信号通路来讨论 ncRNAs 在 DNA 修复不同方面贡献的最新进展。