Frontotemporal dementia (FTD) is a neurodegenerative disease that presents with profound changes in social cognition. Music might be a sensitive probe for social cognition abilities, but underlying neurobiological substrates are unclear. We performed a meta-analysis of voxel-based morphometry studies in FTD patients and functional MRI studies for music perception and social cognition tasks in cognitively normal controls to identify robust patterns of atrophy (FTD) or activation (music perception or social cognition). Conjunction analyses were performed to identify overlapping brain regions. In total 303 articles were included: 53 for FTD (n = 1153 patients, 42.5% female; 1337 controls, 53.8% female), 28 for music perception (n = 540, 51.8% female) and 222 for social cognition in controls (n = 5664, 50.2% female). We observed considerable overlap in atrophy patterns associated with FTD, and functional activation associated with music perception and social cognition, mostly encompassing the ventral language network. We further observed overlap across all three modalities in mesolimbic, basal forebrain and striatal regions. The results of our meta-analysis suggest that music perception and social cognition share neurobiological circuits that are affected in FTD. This supports the idea that music might be a sensitive probe for social cognition abilities with implications for diagnosis and monitoring.

额颞痴呆（FTD）是一种神经退行性疾病，其社会认知发生了深刻变化。音乐可能是对社交认知能力的敏感探究，但尚不清楚潜在的神经生物学底物。我们对FTD患者的基于体素的形态学研究和功能性MRI研究进行了荟萃分析，用于认知正常对照中的音乐知觉和社交认知任务，以识别出萎缩（FTD）或激活（音乐知觉或社交认知）的稳健模式。进行联合分析以识别重叠的大脑区域。总共包括303篇文章：FTD的53篇（n = 1153名患者，女性42.5％；对照组1337例，女性53.8％），音乐知觉28篇（n = 540，女性51.8％），对照组中的社会认知222篇（n = 5664，女性占50.2％）。我们观察到与FTD相关的萎缩模式和与音乐感知和社交认知相关的功能激活存在大量重叠，其中大部分包含腹侧语言网络。我们进一步观察到中边缘，基底前脑和纹状体区域的所有三种模式都有重叠。我们的荟萃分析结果表明，音乐知觉和社会认知共享受FTD影响的神经生物学回路。这支持了这样的观点，即音乐可能是对社会认知能力的敏感探究，对诊断和监测具有影响。基底前脑和纹状体区域。我们的荟萃分析结果表明，音乐知觉和社会认知共享受FTD影响的神经生物学回路。这支持了这样的观点，即音乐可能是对社会认知能力的敏感探究，对诊断和监测具有影响。基底前脑和纹状体区域。我们的荟萃分析结果表明，音乐知觉和社会认知共享受FTD影响的神经生物学回路。这支持了这样的观点，即音乐可能是对社会认知能力的敏感探究，对诊断和监测具有影响。