Antioxidants can protect organization from damage by scavenging of free radicals. When two kinds of antioxidants are consumed together, the total antioxidant capacity might be enhanced via synergistic interactions. Herein, we develop a simple, direct, and effective strategy to quantify the synergistic interaction between ascorbic acid (AA) and other different antioxidants by photoelectrochemical (PEC) technology. MXene Ti₃C₂–TiO₂ composites fabricated via hydrogen peroxide oxidation were applied as sensing material for the antioxidants interaction study. Under excitation of 470 nm wavelength, the photogenerated electrons transfer from the conduction band of TiO₂ nanoparticles to the Ti₃C₂ layers, and the holes in TiO₂ can oxidize antioxidants, leading to an enhanced photocurrent as the detection signal. This PEC sensor exhibits a good linear range to AA concentrations from 12.48 to 521.33 μM as well as obvious antioxidants capability synergism. In particular, the photocurrents of AA + gallic acid (GA) and AA + chlorogenic acid (CHA) mixtures at 476.19 μM increase 1.95 and 2.35 times respectively comparing with the sum of photocurrents of AA and GA or CHA. It is found that the synergistic effect is mainly depending on the fact that AA with the low redox potential (0.246 V vs NHE) can reduce other antioxidants radical to promote regeneration, improving the overall antioxidant performance. Moreover, it is proved that the greater redox potential of antioxidants, the more obvious the synergistic effect. In addition, the sensor was used to real sample assay, which provides available information towards food nutrition analysis, health products design and quality inspection.

抗氧化剂可以通过清除自由基来保护组织免受损害。当两种抗氧化剂一起食用时，总的抗氧化剂能力可能会通过协同相互作用而增强。本文中，我们开发了一种简单，直接且有效的策略，以通过光电化学（PEC）技术量化抗坏血酸（AA）与其他不同抗氧化剂之间的协同相互作用。通过过氧化氢氧化制备的MXene Ti ₃ C ₂ -TiO ₂复合材料被用作抗氧化剂相互作用研究的传感材料。在470 nm波长的激发下，光生电子从TiO ₂纳米粒子的导带转移到Ti ₃ C _2。层和TiO _2中的孔会氧化抗氧化剂，导致增强的光电流作为检测信号。该PEC传感器在从12.48至521.33μM的AA浓度范围内表现出良好的线性范围，并且具有明显的抗氧化剂功能协同作用。尤其是，AA +没食子酸（GA）和AA +绿原酸（CHA）混合物在476.19μM的光电流分别比AA和GA或CHA的光电流之和增加1.95倍和2.35倍。发现协同效应主要取决于以下事实：具有低氧化还原电势（0.246 V vs NHE）的AA可以减少其他抗氧化剂自由基以促进再生，从而改善总体抗氧化剂性能。此外，已证明抗氧化剂的氧化还原电势越大，协同作用越明显。此外，该传感器还用于实际样品分析，