T lymphocytes (T cells) are the major mediators of adaptive immune response. They detect pathogens primarily via the interaction of their T cell receptor (TCR) with the cognate pathogen-derived peptide displayed in the context of MHC on the infected cell. A critical step in T cell activation is the formation of immunological synapse, a specialized cell–cell conjugate interface between the T cell and infected cell, where massive TCR-induced actin remodeling and polymerization take place. Dynamic actin polymerization at the immunological synapse is essential for T cell activation and subsequently, immune response.

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T 细胞免疫突触中肌动蛋白结构的形态学定义

T淋巴细胞（T细胞）是适应性免疫反应的主要介质。它们主要通过它们的 T 细胞受体 (TCR) 与在受感染细胞上的 MHC 背景下展示的同源病原体衍生肽的相互作用来检测病原体。T 细胞活化的关键步骤是免疫突触的形成，这是 T 细胞和受感染细胞之间专门的细胞 - 细胞结合界面，在那里发生大量 TCR 诱导的肌动蛋白重塑和聚合。免疫突触的动态肌动蛋白聚合对于 T 细胞活化和随后的免疫反应至关重要。