Four unknown stilbenoids, including one dimer, namely 4′-methoxy-scirpusin A (5) and three monomeric stilbene glycosides, namely piceatannol-3′-O-[2′′-(3,5-dihydroxy-4-methoxybenzoyl)]-β-d-glucopyranoside (13), piceatannol-3′-O-(2′′-galloyl)-β-d-glucopyranoside (14) and piceatannol-3′-O-(6″-p-coumaroyl)-β-d-glucopyranoside (16) together with 15 described compounds, were isolated from the ethyl acetate fraction of the ethanol extract of roots of Rheum lhasaense based on the guidance of the inhibitory effect on acetylcholinesterase. The structures of the unknown compounds were established by combined spectroscopic analysis and comparing their spectral data with compounds with similar structures. Some selected components were also investigated for their inhibitory abilities on acetylcholinesterase (AChE), indicating that compound 13 may be responsible for higher inhibitory activity of the ethyl acetate fraction on AChE.

四种未知的类芪类化合物，包括一个二聚体，即4'-甲氧基-鞘氨醇A（5）和三个单体二苯乙烯苷，即piceatannol-3'- O- [2''-（3,5-二羟基-4-甲氧基苯甲酰基）] -β- d-吡喃葡萄糖苷（13），皮甲三醇3'- O-（2''-没食子酰基）-β- d-吡喃葡萄糖苷（14）和皮甲酚3'- O-（6″ -p-香豆酰）从大黄大黄根乙醇提取物的乙酸乙酯馏分中分离出β- d-吡喃葡萄糖苷（16）和15种所述化合物基于对乙酰胆碱酯酶的抑制作用的指导。未知化合物的结构是通过组合光谱分析并将其光谱数据与具有相似结构的化合物进行比较而建立的。还研究了一些选定的组分对乙酰胆碱酯酶（AChE）的抑制能力，表明化合物13可能是乙酸乙酯级分对AChE的更高抑制活性。