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Analysis of chemical compounds and toxicological evaluation of Forsythia suspensa leaves tea
Food Science and Biotechnology ( IF 2.9 ) Pub Date : 2021-01-06 , DOI: 10.1007/s10068-020-00855-y
Da-Hong Wang 1, 2, 3 , Meng-Yang Wang 1 , Wen-Hao Shen 1 , Jiang-Feng Yuan 1, 2, 3
Affiliation  

To determine the compositions of Forsythia suspensa leaves tea (FSLT) and its safety, the chemical compounds were analysed with some methods, and the toxicity was evaluated in Kunming mice and Wistar rats. The results showed that FSLT contained rich flavonoid, lignans, triperpene acids, amino acids, and mineral elements. In the acute toxicity study, none of the mice died, and no obvious poisoning symptoms were observed after 14 days in mice at the dose of 15 mg/g·body weight (bw) FSLT; in the sub-chronic toxicity, no abnormal or dead rat was found at the dose of 1, 3, and 10 mg/g·bw during 90 days feeding administration; there was no significant difference in bw and food consumption; no significant differences were found in each hematology and serum biochemistry parameter and organ/body weight ratio comparing with the control experimental group. The results revealed that the FSLT has low or no toxicity via oral administration. Therefore, FSLT is very suitable and safe to be used as a new resource food.



中文翻译:

连翘叶茶的化学成分分析及毒理学评价

确定连翘的成分叶茶(FSLT)及其安全性,用一些方法分析了化学成分,并在昆明小鼠和Wistar大鼠中评估了毒性。结果表明,FSLT含有丰富的类黄酮、木脂素、三萜酸、氨基酸和矿物质元素。急性毒性研究中,15mg/g·体重(bw)FSLT给药14天后,小鼠无一死亡,未见明显中毒症状;亚慢性毒性方面,1、3、10mg/g·bw给药90天未见异常或死亡大鼠;体重和食物消费没有显着差异;各项血液学和血清生化指标及器官/体重比与对照组比较无显着性差异。结果表明,FSLT通过口服给药具有低毒性或无毒性。因此,FSLT作为一种新的资源食品是非常适合和安全的。

更新日期:2021-01-07
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