This study was conducted to evaluate the probiotic properties and antioxidant activities of lactic acid bacteria strains including Levilactobacillus brevis KU15147 isolated from kimchi to determine their potential as a probiotic. The tolerance of all strains to gastric acid and bile salts was more than 90%. The strains did not produce a β-glucuronidase and survived following treatment with gentamicin, kanamycin, streptomycin, and ciprofloxacin. L. brevis KU15147 showed greater adhesion activity to HT-29 cells (6.38%) and its antioxidant activities were higher than those of other tested strains, showing values of 38.56%, 22%, and 23.82% in DPPH, ABTS, and β-carotene bleaching assays, respectively. Additionally, the relative expression intensities of induced nitric oxide synthase and tumor necrosis factor-α of L. brevis KU15147 were greater than those of other strains, suggesting that this strain can be applied in the health food or pharmaceutical industry as a novel probiotic strain.

本研究旨在评估从泡菜中分离的乳酸菌菌株（包括短乳酸杆菌KU15147）的益生菌特性和抗氧化活性，以确定它们作为益生菌的潜力。所有菌株对胃酸和胆汁盐的耐受性均在90%以上。这些菌株不产生β-葡萄糖醛酸酶，并且在用庆大霉素、卡那霉素、链霉素和环丙沙星处理后存活。短乳杆菌KU15147对HT-29细胞具有更强的粘附活性（6.38%），其抗氧化活性高于其他被测菌株，在DPPH、ABTS和β-胡萝卜素漂白试验中分别为38.56%、22%和23.82% ， 分别。此外，短乳杆菌KU15147诱导一氧化氮合酶和肿瘤坏死因子-α的相对表达强度高于其他菌株，表明该菌株可作为一种新型益生菌菌株应用于保健食品或医药行业。