Different types of hybrid organic–inorganic compounds were investigated as antibacterial agents. These compounds have exhibited reasonable antibacterial activity with lower cytotoxicity. Herein, compounds [Ag6(MBT)6] (1) and [Cu6(MBT)6] (2) (HMBT: 2-mercaptobenzothiazole) were synthesized by using the reflux method (1b, 2b) and sonochemical process (1s, 2s). The obtained products were characterized by powder X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, and scanning electron microscopy. Then, their antibacterial activity was investigated by using the agar well diffusion method, and the results were reported by inhibition zone diameter. The results showed that nanosized samples were more active against bacteria because of their higher surface area. These two compounds showed different antibacterial activities, and the silver-based complex is a better antibacterial agent against both strains of bacteria which is attributed to the different mechanisms of Ag(I) and Cu(I) ions in antimicrobial action. They also showed a reasonable antibacterial effect that was comparable to other types of hybrid organic–inorganic compounds. Graphical abstract The antimicrobial effect of two polynuclear complexes from Ag and Cu is investigated. They have different antibacterial activities. Ag(I) and Cu(I) ions have different mechanism in antimicrobial action. Their antibacterial effect was comparable to other types of metal complexes. The antimicrobial effect of two polynuclear complexes from Ag and Cu is investigated. They have different antibacterial activities. Ag(I) and Cu(I) ions have different mechanism in antimicrobial action. Their antibacterial effect was comparable to other types of metal complexes.

中文翻译：

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银铜金属有机杂化纳米材料的合成、表征及其生物学应用

研究了不同类型的混合有机-无机化合物作为抗菌剂。这些化合物表现出合理的抗菌活性和较低的细胞毒性。本文采用回流法(1b, 2b)和声化学法(1s, 2s)合成了化合物[Ag6(MBT)6] (1)和[Cu6(MBT)6] (2) (HMBT: 2-mercaptobenzothiazole) ）。所得产物通过粉末X射线衍射、热重分析、红外光谱和扫描电子显微镜表征。然后，采用琼脂孔扩散法研究了它们的抗菌活性，并以抑菌圈直径报告了结果。结果表明，纳米尺寸的样品具有更高的表面积，因此对细菌更具活性。这两种化合物表现出不同的抗菌活性，银基复合物对两种细菌都是更好的抗菌剂，这归因于 Ag(I) 和 Cu(I) 离子在抗菌作用中的不同机制。它们还显示出与其他类型的混合有机-无机化合物相当的抗菌效果。图形摘要 研究了来自 Ag 和 Cu 的两种多核配合物的抗菌作用。它们具有不同的抗菌活性。Ag(I) 和 Cu(I) 离子具有不同的抗菌作用机制。它们的抗菌作用可与其他类型的金属配合物相媲美。研究了来自 Ag 和 Cu 的两种多核配合物的抗菌作用。它们具有不同的抗菌活性。Ag(I) 和 Cu(I) 离子具有不同的抗菌作用机制。