Objectives

This study examines the influence of high-definition transcranial direct current stimulation (HD-tDCS) of the prefrontal cortex (PFC) on aggressive behavior and antisocial intentions, and provides an updated meta-analysis of prior studies.

Methods

In this double-blind, stratified, randomized, sham-controlled, parallel-group trial, 94 participants received sham or 20 min of 2 mA anodal stimulation of the PFC using HD-tDCS. The Voodoo Doll Task and hypothetical vignettes were used to measure aggressive behavior and antisocial intentions, respectively.

Results

There were no significant group differences in aggressive behavior or antisocial intentions after stimulation.

Conclusions

To the authors’ knowledge, this is the first study to examine HD-tDCS in reducing aggressive and antisocial behavior. The null effects on aggressive behavior align with an updated meta-analysis of prior studies (d = − 0.028, 95% CI [− 1.14, 1.08]). Future studies employing repeated tDCS sessions on significantly antisocial populations could further help assess the utility of tDCS for reducing antisociality.

中文翻译：

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前额叶皮层刺激对攻击性和反社会行为的影响：一项双盲，分层，随机，假对照对照，平行组试验

目标

这项研究检查了前额叶皮层（PFC）的高清经颅直流电刺激（HD-tDCS）对攻击行为和反社会意图的影响，并提供了先前研究的最新荟萃分析。

方法

在这项双盲，分层，随机，假手术对照的平行组试验中，有94名参与者接受了假手术或使用HD-tDCS进行20分钟的2 mA阳极刺激PFC。伏都教玩偶任务和假设的小插曲分别用于衡量攻击行为和反社会意图。

结果

刺激后，攻击行为或反社会意图没有明显的群体差异。

结论

据作者所知，这是研究HD-tDCS在减少攻击性和反社会行为方面的第一项研究。对攻击行为的无效影响与先前研究的最新荟萃分析 相符（d =-0.028，95％CI [-1.14，1.08]）。未来针对大量反社会人群采用重复tDCS会议的研究可能会进一步帮助评估tDCS在减少反社会性方面的效用。