OBJECTIVE Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism's moderation effect on resilience scores in response to cognitive therapy. METHOD A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. RESULTS The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). CONCLUSION Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism.

中文翻译：

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BDNF Val66Met 多态性和重度抑郁症的恢复力：认知心理治疗的影响

目的 重度抑郁症恢复力的临床和生物学相关性很少。我们旨在研究 BDNF 基因中 Val66Met 多态性对重度抑郁症患者恢复力评分的影响，并评估多态性对认知治疗后恢复力评分的调节作用。方法 共有 106 名重度抑郁症患者参加了这项临床随机研究。在基线、治疗后和六个月的随访中应用韧性量表和汉密尔顿抑郁量表。在基线时获得血样用于分子分析。结果 Met 等位基因患者的基线弹性评分 (114.6±17.6) 高于 Val/Val 基因型患者 (104.04±21.05; p = 0.037)。认知疗法治疗增加了弹性评分（p ≤ 0.001）并减少了抑郁症状（p ≤ 0.001）。在混合效应模型中，Val/Val 基因型代表恢复力评分降低（t218 = -1.98；p = 0.048），Val66Met 多态性与性别相互作用以预测认知治疗期间总恢复力评分的增加（t218 = 2.69；p = 0.008)。结论我们的结果表明，考虑到性别和遗传易感性是由 Val66Met 多态性预测的，认知治疗干预可以提高随访中的恢复力。Val66Met 多态性与性别相互作用以预测认知治疗期间总弹性分数的增加（t218 = 2.69；p = 0.008）。结论我们的结果表明，考虑到性别和遗传易感性是由 Val66Met 多态性预测的，认知治疗干预可以提高随访中的恢复力。Val66Met 多态性与性别相互作用以预测认知治疗期间总弹性分数的增加（t218 = 2.69；p = 0.008）。结论我们的结果表明，考虑到性别和遗传易感性是由 Val66Met 多态性预测的，认知治疗干预可以提高随访中的恢复力。