OBJECTIVE Sepsis survivors present a wide range of sequelae; few studies have evaluated psychiatric disorders after sepsis. The objective of this study was to define the prevalence of and risk factors for anxiety, depression and post-traumatic stress disorder (PTSD) symptoms in sepsis survivors. METHOD Anxiety, depression and post-traumatic stress symptoms in severe sepsis and septic shock survivors 24 h and 1 year after intensive care unit (ICU) discharge were assessed using the Beck Anxiety/Depression Inventories and the PTSD Checklist-Civilian Version. Differences in psychiatric symptoms over time and the influence of variables on these symptoms were calculated with marginal models. RESULTS A total of 33 patients were enrolled in the study. The frequencies of anxiety, depression and PTSD 24 h after ICU discharge were 67%, 49%, and 46%, respectively and, among patients re-evaluated 1 year after ICU discharge, the frequencies were 38%, 50%, and 31%, respectively. Factors associated with PTSD included serum S100B level, age, and Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) score. Factors associated with depression included patient age and cumulative dose of dobutamine. IQCODE score and cumulative dose of haloperidol in the ICU were associated with anxiety after ICU discharge. CONCLUSION Patients who survive sepsis have high levels of psychiatric symptoms. Sepsis and associated treatment-related exposures may have a role in increasing the risk of subsequent depression, anxiety, and PTSD.

中文翻译：

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ICU 出院后脓毒症幸存者创伤后压力、焦虑和抑郁的患病率和危险因素

目的 脓毒症幸存者存在多种后遗症；很少有研究评估败血症后的精神障碍。本研究的目的是确定脓毒症幸存者焦虑、抑郁和创伤后应激障碍 (PTSD) 症状的患病率和危险因素。方法 使用贝克焦虑/抑郁量表和 PTSD 检查表 - 民用版评估重症脓毒症和感染性休克幸存者出院 24 小时和 1 年后的焦虑、抑郁和创伤后应激症状。使用边际模型计算精神症状随时间的差异以及变量对这些症状的影响。结果 共有 33 名患者参加了这项研究。ICU 出院 24 小时后焦虑、抑郁和 PTSD 的发生率分别为 67%、49% 和 46%，ICU 出院 1 年后重新评估的患者中，频率分别为 38%、50% 和 31%。与 PTSD 相关的因素包括血清 S100B 水平、年龄和老年人认知衰退的知情问卷 (IQCODE) 评分。与抑郁症相关的因素包括患者年龄和多巴酚丁胺的累积剂量。ICU中IQCODE评分和氟哌啶醇累积剂量与ICU出院后的焦虑相关。结论 从败血症中存活下来的患者具有高度的精神症状。脓毒症和相关的治疗相关暴露可能会增加随后出现抑郁、焦虑和 PTSD 的风险。年龄和老年人认知能力下降的知情调查问卷 (IQCODE) 评分。与抑郁症相关的因素包括患者年龄和多巴酚丁胺的累积剂量。ICU中IQCODE评分和氟哌啶醇累积剂量与ICU出院后的焦虑相关。结论 从败血症中存活下来的患者具有高度的精神症状。脓毒症和相关的治疗相关暴露可能会增加随后出现抑郁、焦虑和 PTSD 的风险。年龄和老年人认知能力下降的知情调查问卷 (IQCODE) 评分。与抑郁症相关的因素包括患者年龄和多巴酚丁胺的累积剂量。ICU中IQCODE评分和氟哌啶醇累积剂量与ICU出院后的焦虑相关。结论 从败血症中存活下来的患者具有高度的精神症状。脓毒症和相关的治疗相关暴露可能会增加随后出现抑郁、焦虑和 PTSD 的风险。结论 从败血症中幸存下来的患者具有高度的精神症状。脓毒症和相关的治疗相关暴露可能会增加随后出现抑郁、焦虑和 PTSD 的风险。结论 从败血症中存活下来的患者具有高度的精神症状。脓毒症和相关的治疗相关暴露可能会增加随后出现抑郁、焦虑和 PTSD 的风险。