OBJECTIVE The increased prevalence rate of white matter hyperintensities is one of the most consistently reported brain abnormalities in adults with bipolar disorder. However, findings in children and adolescents with bipolar disorder are less consistent. Prior studies have been constrained by small sample sizes and/or poor age- and sex-matching of healthy controls. We examined this topic in the largest sample of adolescents with bipolar disorder to date. METHODS T2-weighted 3-Tesla magnetic resonance imaging data were acquired for 83 adolescents with bipolar disorder diagnosed via the Kiddie Schedule for Affective Disorders and the Schizophrenia, Present and Lifetime version semi-structured interview and 64 age- and sex-matched healthy controls. All acquired scans were examined by neuroradiologists and the presence or absence of white matter hyperintensities was determined for each participant. RESULTS The prevalence of white matter hyperintensities did not differ between adolescents with bipolar disorder (13.3%) and controls (21.9%; χ2 = 1.90; p = 0.168). CONCLUSION In contrast to the study hypothesis, the prevalence of white matter hyperintensities was not higher in adolescents with bipolar disorder than controls. The large sample size and good matching for age and sex bolster the reliability of this negative finding. Future studies are warranted to evaluate the prevalence, incidence, and predictors of white matter hyperintensities in early-onset bipolar disorder prospectively.

中文翻译：

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在大量患有双相情感障碍的青少年和年轻成人样本中，白质高信号的患病率并未升高

目的 白质高信号的患病率增加是双相情感障碍成人中最一致报告的大脑异常之一。然而，在患有双相情感障碍的儿童和青少年中的发现不太一致。先前的研究受到样本量小和/或健康对照的年龄和性别匹配不佳的限制。我们在迄今为止最大的双相情感障碍青少年样本中研究了这个主题。方法 T2 加权 3-Tesla 磁共振成像数据采集了 83 名通过情感障碍和精神分裂症儿童计划诊断出的双相情感障碍青少年，现在和终生版本的半结构化访谈以及 64 名年龄和性别匹配的健康对照。所有获得的扫描均由神经放射科医生检查，并确定每位参与者是否存在白质高信号。结果 双相障碍青少年 (13.3%) 和对照组 (21.9%; χ2 = 1.90; p = 0.168) 的白质高信号患病率没有差异。结论与研究假设相反，双相情感障碍青少年白质高信号的患病率并不高于对照组。大样本量和年龄和性别的良好匹配增强了这一负面发现的可靠性。未来的研究需要前瞻性地评估早发性双相情感障碍中白质高信号的患病率、发生率和预测因素。结果 双相障碍青少年 (13.3%) 和对照组 (21.9%; χ2 = 1.90; p = 0.168) 的白质高信号患病率没有差异。结论与研究假设相反，双相情感障碍青少年白质高信号的患病率并不高于对照组。大样本量和年龄和性别的良好匹配增强了这一负面发现的可靠性。未来的研究需要前瞻性地评估早发性双相情感障碍中白质高信号的患病率、发病率和预测因素。结果 双相障碍青少年 (13.3%) 和对照组 (21.9%; χ2 = 1.90; p = 0.168) 的白质高信号患病率没有差异。结论与研究假设相反，双相情感障碍青少年白质高信号的患病率并不高于对照组。大样本量和年龄和性别的良好匹配增强了这一负面发现的可靠性。未来的研究需要前瞻性地评估早发性双相情感障碍中白质高信号的患病率、发生率和预测因素。双相情感障碍青少年白质高信号的患病率并不高于对照组。大样本量和年龄和性别的良好匹配增强了这一负面发现的可靠性。未来的研究需要前瞻性地评估早发性双相情感障碍中白质高信号的患病率、发病率和预测因素。双相情感障碍青少年白质高信号的患病率并不高于对照组。大样本量和年龄和性别的良好匹配增强了这一负面发现的可靠性。未来的研究需要前瞻性地评估早发性双相情感障碍中白质高信号的患病率、发病率和预测因素。