Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

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感染后长达 8 个月评估对 SARS-CoV-2 的免疫记忆

了解 SARS-CoV-2 的免疫记忆对于改进诊断和疫苗以及评估 COVID-19 大流行的未来进程至关重要。我们分析了 188 例 COVID-19 病例的 254 个样本中针对 SARS-CoV-2 的循环免疫记忆的多个区室，其中包括感染后 6 个月以上的 43 个样本。刺突蛋白 IgG 在 6 个多月内相对稳定。症状出现后 6 个月时，刺突特异性记忆 B 细胞比症状出现后 1 个月时更加丰富。SARS-CoV-2 特异性 CD4+ T 细胞和 CD8+ T 细胞下降，半衰期为 3-5 个月。通过综合研究抗体、记忆 B 细胞、CD4+ T 细胞和 CD8+ T 细胞对 SARS-CoV-2 的记忆，我们观察到 SARS-CoV-2 免疫记忆的每个组成部分都表现出不同的动力学。