Terbinafine hydrochloride is a potent antifungal drug indicated for oral and topical treatment of mycoses. A resonance Rayleigh scattering (RRS) method was developed for the determination of terbinafine hydrochloride through a feasible complexation reaction with erythrosine B. In a weakly acidic medium (acetate buffer, pH 5.0), terbinafine hydrochloride can react with erythrosine B through the electrostatic attraction and virtue of hydrophobic force to form an ion-association complex. The reaction resulted in the appearance of a new RRS peak at 369 nm. The RRS peak was increased by increasing the concentration of terbinafine hydrochloride in the linear range of 0.1–1.5 µg ml⁻¹. All the reaction conditions (erythrosine B concentration, buffer volume, diluting solvent and pH) were optimized. The detection limit was 0.029 µg ml⁻¹ while the quantitation limit was 0.089 µg ml⁻¹. The suggested method after its validation was successfully applied for the determination of terbinafine hydrochloride in different pharmaceutical formulations (tablets and cream) with sufficient recovery.

盐酸特比萘芬是一种有效的抗真菌药物，用于口服和局部治疗真菌病。建立了一种共振瑞利散射（RRS）方法，通过与赤藓红B发生可行的络合反应来测定盐酸特比萘芬。在弱酸性介质（醋酸盐缓冲液，pH 5.0）中，盐酸特比萘芬与赤藓红B通过静电引力作用而发生反应。凭借疏水力形成离子缔合络合物。该反应导致在 369 nm 处出现新的 RRS 峰。通过在0.1–1.5 µg ml ^-1线性范围内增加盐酸特比萘芬的浓度，RRS 峰增加。所有反应条件（赤藓红 B 浓度、缓冲液体积、稀释溶剂和 pH）均经过优化。检测限为0.029 µg ml ^-1 ，定量限为0.089 µg ml ^-1 。建议的方法经验证后已成功应用于不同药物制剂（片剂和乳膏）中盐酸特比萘芬的测定，并具有足够的回收率。