Metal-free visible-light-induced photoredox-catalyzed intermolecular pyridylation/phosphinoylation of alkenes,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metal-free visible-light-induced photoredox-catalyzed intermolecular pyridylation/phosphinoylation of alkenes
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-12-22 , DOI: 10.1039/d0qo01218a
Jiaxuan Shen _{1,

2,

3,

4,

5} , Yipin Zhang _{1,

2,

3,

4,

5} , Yanjiang Yu _{1,

2,

3,

4,

5} , Manman Wang _{1,

2,

3,

4,

5}

Affiliation

Reported here is an intermolecular pyridylation/phosphinoylation of alkenes using 4-cyanopyridine and diphenylphosphine oxide under visible-light-induced organic photoredox catalysis. The reaction occurs under mild metal-free conditions, possessing a broad substrate scope. The protocol can be practiced on a gram scale and applied to the modification of natural product-derived and medicinally relevant complex molecules containing a styrene unit. Mechanistic investigations suggest that triethylamine serves as both single-electron transfer (SET) and hydrogen atom transfer (HAT) agents.

中文翻译：

无金属的可见光诱导的光氧化还原催化烯烃的分子间吡啶/膦酰基化

此处报道的是在可见光诱导的有机光氧化还原催化下，使用4-氰基吡啶和二苯基氧化膦进行烯烃的分子间吡啶基化/膦酰基化。该反应在温和的无金属条件下进行，具有广泛的底物范围。该规程可以以克为单位进行实践，并适用于天然产物衍生的和含有苯乙烯单元的医学上相关的复杂分子的修饰。机理研究表明，三乙胺既可以用作单电子转移（SET）剂，又可以用作氢原子转移（HAT）剂。

更新日期：2021-01-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11