In comparison with enzymatic detection, non-enzymatic detection of glucose has lower cost, better stability, and simpler immobilization operation, but it still lacks sensitivity. Rational design and controllable synthesis of materials with unique morphology are important for non-enzymatic glucose detection. Herein, graphene oxide (GO) is utilized as structure-directing agent for the hydrothermal synthesis of Ni-BTC, followed by pyrolysis to obtain graphene decorated with Ni nanoparticles and carbon (Ni/C/G). GO confines the growth of Ni nanoparticles and GO-derived graphene improves the dispersion of Ni nanoparticles. Ni/C/G demonstrates higher sensitivity for non-enzymatic glucose electrochemical detection. In contrast, pyrolysis of Ni-BTC without GO produces micro-size rod-like Ni/C with poor performance towards glucose detection. Thus, the introduction of GO as the stabilizer in the hydrothermal synthesis of Ni-BTC is an effective approach to synthesize electrocatalysts containing metal nanoparticles. Furthermore, this strategy can be utilized to synthesize other low-cost nanomaterials for non-enzyme glucose detection.

与酶法检测相比，非酶法检测葡萄糖成本更低，稳定性更好，固定化操作更简单，但仍缺乏灵敏度。具有独特形态的材料的合理设计和可控合成对于非酶促葡萄糖检测很重要。在此，氧化石墨烯（GO）被用作水热合成 Ni-BTC 的结构导向剂，然后热解得到用 Ni 纳米颗粒和碳装饰的石墨烯（Ni/C/G）。GO 限制了 Ni 纳米粒子的生长，GO 衍生的石墨烯改善了 Ni 纳米粒子的分散。Ni/C/G 对非酶葡萄糖电化学检测表现出更高的灵敏度。相比之下，没有 GO 的 Ni-BTC 的热解会产生微尺寸棒状 Ni/C，对葡萄糖检测性能较差。因此，在 Ni-BTC 的水热合成中引入 GO 作为稳定剂是合成含有金属纳米粒子的电催化剂的有效方法。此外，该策略可用于合成其他用于非酶葡萄糖检测的低成本纳米材料。