Background:Coronary artery disease (CAD) increases risk for vascular cognitive impairment-no dementia (VCIND), a precursor to dementia, potentially through persistent oxidative stress. Objective:This study assessed peripheral glutathione peroxidase activity (GPX), which is protective against oxidative stress, in VCIND versus cognitively normal CAD controls (CN). GPX activity was also evaluated as a biomarker of cognition, particularly verbal memory. Methods:120 CAD patients with VCIND (1SD below norms on executive function or verbal memory (VM)) or without (CN) participated in exercise rehabilitation for 24 weeks. Neurocognitive and cardiopulmonary fitness (VO2 peak) assessments and plasma were collected at baseline and 24-weeks. Results:GPX was higher in VCIND compared to CN (F1,119 = 3.996, p = 0.048). Higher GPX was associated with poorer baseline VM (β= –0.182, p = 0.048), and longitudinally with VM decline controlling for sex, body mass index, VO2 peak, and education (b[SE] = –0.02[0.01], p = 0.004). Only CN participants showed improved VM performance with increased fitness (b[SE] = 1.30[0.15], p < 0.005). Conclusion:GPX was elevated in VCIND consistent with a compensatory response to persistent oxidative stress. Increased GPX predicted poorer cognitive outcomes (verbal memory) in VCIND patients despite improved fitness.

中文翻译：

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谷胱甘肽过氧化物酶活性在血管认知障碍 - 无痴呆症中发生改变，是语言记忆表现的潜在标志物

背景：冠状动脉疾病 (CAD) 可能通过持续的氧化应激增加血管性认知障碍 - 无痴呆 (VCIND) 的风险，这是痴呆的前兆。目的：本研究评估了 VCIND 与认知正常 CAD 对照 (CN) 的外周谷胱甘肽过氧化物酶活性 (GPX)，该活性可防止氧化应激。GPX 活性也被评估为认知的生物标志物，特别是语言记忆。方法：120例VCIND（执行功能或语言记忆（VM）低于标准1SD）或无（CN）CAD患者参加24周的运动康复治疗。在基线和 24 周收集神经认知和心肺健康（VO2 峰值）评估和血浆。结果：与 CN 相比，VCIND 中的 GPX 更高（F1,119 = 3.996，p = 0.048）。较高的 GPX 与较差的基线 VM 相关（β= –0.182，p = 0.048），并且纵向与控制性别、体重指数、VO2 峰值和教育的 VM 下降相关（b[SE] = –0.02[0.01]，p = 0.004）。只有 CN 参与者表现出更好的 VM 性能和更好的适应度（b[SE] = 1.30[0.15]，p < 0.005）。结论： VCIND 中 GPX 升高，与对持续氧化应激的代偿反应一致。尽管健康状况有所改善，但增加的 GPX 预测了 VCIND 患者较差的认知结果（语言记忆）。GPX 在 VCIND 中升高，与对持续氧化应激的补偿反应一致。尽管健康状况有所改善，但增加的 GPX 预测了 VCIND 患者较差的认知结果（语言记忆）。GPX 在 VCIND 中升高，与对持续氧化应激的补偿反应一致。尽管健康状况有所改善，但增加的 GPX 预测了 VCIND 患者较差的认知结果（语言记忆）。