To investigate the feasibility of β-tricalcium phosphate (TCP)/gelatine scaffold combined with allogeneic adipose-derived stem cells (ASCs) to repair hole shape defect, third-passage ASCs were seeded onto composite scaffolds to prepare an ASC-β-TCP/gelatine tissue-engineered bone to pack into the rabbit cavernous bone defects of experimental groups. In animal models, the bone defect area was completely filled and difficult to recognize in the experimental group at 12 weeks post-surgery by gross observation and radiographic examination. The average bone mineral density value of them was higher than that of the control group. Because of the biocompatibility with allogenic ASCs and the osteoconductivity of β-TCP/gelatine scaffolds, β-TCP/gelatine is suitable as a plastic scaffold for the ASC-seeded tissue-engineered bone to repair cavernous defects.

中文翻译：

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一种用同种异体脂肪干细胞接种的用于修复兔骨缺损的塑料 β-磷酸三钙/明胶支架

为了研究β-磷酸三钙（TCP）/明胶支架联合同种异体脂肪干细胞（ASCs）修复孔形缺陷的可行性，将第三代ASCs接种到复合支架上制备ASC-β-TCP/明胶组织工程骨填充到实验组的兔海绵状骨缺损中。在动物模型中，实验组在术后12周肉眼观察和X线检查时，骨缺损区完全填满，难以识别。他们的平均骨密度值高于对照组。由于与同种异体 ASCs 的生物相容性和 β-TCP/明胶支架的骨传导性，β-TCP/明胶适合作为 ASC 种子组织工程骨修复海绵状缺损的塑料支架。