Background: Major depressive disorder (MDD) is a mood disorder associated with disruptions in emotional control. Previous studies have investigated abnormal regional activity and connectivity within the fronto-limbic circuit. However, condition-specific connectivity changes and their association with the pathophysiology of MDD remain unexplored. This study investigated effective connectivity in the fronto-limbic circuit induced by negative emotional processing from patients with MDD.

中文翻译：

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重度抑郁症女性患者对负面情绪任务的响应改变了额-边缘回路内的有效连通性

背景：重度抑郁症 (MDD) 是一种与情绪控制中断相关的情绪障碍。以前的研究调查了额边缘回路内的异常区域活动和连通性。然而，条件特定的连接变化及其与 MDD 病理生理学的关联仍未得到探索。本研究调查了由 MDD 患者的负面情绪处理引起的额边缘回路的有效连接。