Objective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups were compared by ANOVA. Correlation was calculated by Pearson or Spearman analysis and binary logistic regression. The ROC curve was also performed. Results. The levels of albumin, serum creatinine (sCr), and IDO in non-CKD patients were significantly different from those in CKD3-CKD5 stages (). IDO was correlated with age, proteinuria, ACR, and eGFR (). After adjusting for CKD-related indices, ln(IDO) was an independent risk factor for CKD (3.48, ). The analysis of ROC curve revealed a best cut­off for IDO was 0.0466 and yielded a sensitivity of 83.8% and a specificity of 75%. Hemoglobin, total protein, and albumin in the ACR1 group were significantly higher than those in the ACR2 and ACR3 groups (), while sCr and IDO levels were significantly lower than those in the ACR2 and ACR3 groups ( or ). After adjusting for CKD-related indices, ln(IDO) was still an independent risk factor for ACR (, ). The analysis of ROC curve revealed a best cut­off for IDO was 0.075 and yielded a sensitivity of 71.9% and a specificity of 72.2%. Conclusion. IDO may be a promising biomarker to predict CKD and assess kidney function.

中文翻译：

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Indoleamine-2,3-Dioxygenase 与慢性肾病的相关性：一项初步研究

客观的。探讨吲哚胺-2,3-双加氧酶(IDO)与慢性肾脏病(CKD)的相关性。方法。共招募了 154 名 CKD 患者和 42 名非 CKD 患者。患者分为ACR1~ACR3（<30 mg/g、30-300 mg/g和>300 mg/g）。通过方差分析比较不同组的生物标志物。通过 Pearson 或 Spearman 分析和二元逻辑回归计算相关性。还进行了 ROC 曲线。结果。非 CKD 患者的白蛋白、血清肌酐（sCr）和 IDO 水平与 CKD3-CKD5 阶段的患者有显着差异。）。IDO 与年龄、蛋白尿、ACR 和 eGFR 相关（）。调整 CKD 相关指标后，ln(IDO) 是 CKD 的独立危险因素 (3.48,）。ROC 曲线分析显示 IDO 的最佳截止值为 0.0466，灵敏度为 83.8%，特异性为 75%。ACR1 组的​​血红蛋白、总蛋白和白蛋白显着高于 ACR2 和 ACR3 组。），而 sCr 和 IDO 水平显着低于 ACR2 和 ACR3 组（或者）。在调整 CKD 相关指标后，ln(IDO) 仍然是 ACR 的独立危险因素（, ）。ROC 曲线分析显示 IDO 的最佳截止值为 0.075，灵敏度为 71.9%，特异性为 72.2%。结论。IDO 可能是预测 CKD 和评估肾功能的有前途的生物标志物。