Inflammatory diseases, whether caused by excessive stress on certain tissues/parts of the body or arising from infections accompanying autoimmune or secondary diseases, have become a problem, especially in the Western world today. Whether these are inflammations of visceral organs, joints, bones, or the like, they are always a physiological reaction of the body, which always tries to eradicate noxious agents and restore tissue homeostasis. Unfortunately, this often results in damage, often irreversible, to the affected tissues. Nevertheless, these inflammatory reactions of the body are the results of excessive stress, strain, and the generally unhealthy environment, in which the people of Western civilization live. The pathophysiology and pathobiochemistry of inflammatory/autoimmune processes are being studied in deep detail, and pharmaceutical companies are constantly developing new drugs that modulate/suppress inflammatory responses and endogenous pro-inflammatory agents. In addition to new specifically targeted drugs for a variety of pro-inflammatory agents, a strategy can be found for the use of older drugs, which are formulated into special nanodrug delivery systems with targeted distribution and often modified release. This contribution summarizes the current state of research and development of nanoformulated anti-inflammatory agents from both conventional drug classes and experimental drugs or dietary supplements used to alleviate inflammatory reactions.

中文翻译：

---

慢性炎性疾病，抗炎药及其递送纳米系统

炎症性疾病，无论是由于对身体某些组织/部位施加过度压力所致，还是由于自身免疫性疾病或继发性疾病引起的感染所致，已成为一个问题，尤其是在当今的西方世界。不管这些是内脏器官，关节，骨骼等的炎症，它们始终是身体的生理反应，总是试图根除有害物质并恢复组织稳态。不幸的是，这经常导致对受影响组织的损害，通常是不可逆的。然而，人体的这些炎症反应是过度压力，劳累以及西方文明人民所居住的普遍不健康环境的结果。炎症/自身免疫过程的病理生理学和病理生物化学正在深入研究，并且制药公司正在不断开发新的药物来调节/抑制炎症反应和内源性促炎药。除了针对各种促炎药的新的靶向药物之外，还可以找到使用较旧药物的策略，这些药物被配制成具有目标分布和经常修饰释放的特殊纳米药物递送系统。该贡献总结了来自常规药物类别和用于减轻炎症反应的实验药物或膳食补充剂的纳米级抗炎剂的研究和开发现状。除了针对各种促炎药的新的靶向药物之外，还可以找到使用较旧药物的策略，这些药物被配制成具有目标分布和经常修饰释放的特殊纳米药物递送系统。该贡献总结了来自常规药物类别和用于减轻炎症反应的实验药物或膳食补充剂的纳米级抗炎剂的研究和开发现状。除了针对各种促炎药的新的靶向药物之外，还可以找到使用较旧药物的策略，这些药物被配制成具有目标分布和经常修饰释放的特殊纳米药物递送系统。该贡献总结了来自常规药物类别和用于减轻炎症反应的实验药物或膳食补充剂的纳米级抗炎剂的研究和开发现状。