Abstract

This paper demonstrated a new and economical methodology using Fe(ClO₄)₂·H₂O as a catalyst for the direct C(sp³)–H functionalization of 2-methyl azaarenes via addition to trifluoromethyl ketones. The use of Fe salts as a Lewis acid catalyst has shown great potential as an accessible, affordable, and effective catalyst for the reaction. Under mild, optimized conditions, an extensive range of 2-alkenylated azaarenes was produced with yields of up to 95%.

中文翻译：

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铁催化的2-甲基氮杂芳烃苄基加成到取代的三氟甲基酮上

抽象的

本文展示了一种新的经济的方法，使用Fe（ClO ₄）₂ ·H ₂ O作为催化剂，通过添加三氟甲基酮将2-甲基氮杂芳烃直接进行C（sp ³）-H官能化。铁盐作为路易斯酸催化剂的使用已显示出巨大的潜力，可作为一种容易获得，负担得起且有效的反应催化剂。在温和，优化的条件下，生产了范围广泛的2-烯基氮杂氮杂芳烃，收率高达95％。