Abstract

Influenza virus infection through seasonal epidemics and occasional pandemics has been a major public health concern for decades. Incomplete protection from vaccination and increased antiviral resistance due to frequent mutations of influenza viruses have led to a continuous need for new therapeutic options. The functional significance of host protein and influenza virus interactions has been established, but relatively less is known about the interaction of host noncoding RNAs, including microRNAs and long noncoding RNAs, with influenza viruses. In this review, we summarize host noncoding RNA profiles during influenza virus infection and the regulation of influenza virus infection by host noncoding RNAs. Influenza viral non-coding RNAs are briefly discussed. Increased understanding of the molecular regulation of influenza viral replication will be beneficial in identifying potential therapeutic targets against the influenza virus.

摘要

几十年来，通过季节性流行病和偶发性大流行引起的流感病毒感染一直是主要的公共卫生问题。由于流感病毒的频繁突变，疫苗接种的保护作用不完全以及抗病毒耐药性的增强，导致对新治疗方法的持续需求。已经确定了宿主蛋白和流感病毒相互作用的功能重要性，但对宿主非编码RNA（包括microRNA和长非编码RNA）与流感病毒相互作用的了解相对较少。在这篇综述中，我们总结了流感病毒感染期间宿主非编码RNA的概况以及宿主非编码RNA对流感病毒感染的调控。简要讨论了流感病毒非编码RNA。