Abstract

Magnetized distilled water (MDW), as a green solvent, was used in the Hantzsch four-component synthesis of polyhydroquinolines and the three-component synthesis of 1,4-dihydropyridine condensation reactions of 1,3-cyclohexanedione/dimedone, ethyl acetoacetate/malononitrile, aldehydes, and ammonium acetate under catalyst-free conditions. The developed synthetic technique offers numerous advantages including eco-friendly, simplicity, low-costs, short reaction times, high reaction yields, and easy work-up compared to the traditional synthetic method. Moreover, the reaction rates were followed spectrophotometrically by monitoring the changes in the absorption spectrum of the reaction mixture in ordinary distilled water (ODW) and MDW. Also, the effect of magnetization time and the memory effect were studied.

摘要

磁化蒸馏水 (MDW) 作为一种绿色溶剂，用于 Hantzsch 四组分合成聚氢喹啉和 1,3-环己二酮/二甲酮、乙酰乙酸乙酯/丙二腈的 1,4-二氢吡啶缩合反应的三组分合成、醛和乙酸铵在无催化剂条件下。与传统合成方法相比，所开发的合成技术具有环保、简单、成本低、反应时间短、反应收率高、易于后处理等诸多优点。此外，通过监测反应混合物在普通蒸馏水（ODW）和MDW中吸收光谱的变化，用分光光度法跟踪反应速率。此外，还研究了磁化时间和记忆效应的影响。