Abstract The alkaline cleavage of two types of sugar nucleotides has been studied by 1H and 31P NMR in order to obtain information on the stability and decomposition pathways in aqueous solutions under alkaline conditions. The reaction of glucose 1-UDP is straightforward, and products are easy to identify. The results obtained with ribose 5-UDP and ribose 5-phosphate reveal, in contrast, a more complex reaction system than expected, and the identification of individual intermediate species was not possible. Even though definite proof for the mechanisms previously proposed could not be obtained, all the spectroscopic evidence is consistent with them. Results also emphasise the significant effect of conditions, pH, ionic strength, and temperature, on the reactivity under chemical conditions.

中文翻译：

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糖核苷酸化学稳定性和反应途径的动力学和核磁共振光谱研究

摘要 为了获得碱性条件下水溶液中稳定性和分解途径的信息，已通过 1 H 和 31 P NMR 研究了两种类型糖核苷酸的碱性裂解。葡萄糖 1-UDP 反应简单，产物易于识别。相比之下，用核糖 5-UDP 和核糖 5-磷酸获得的结果揭示了一个比预期更复杂的反应系统，并且不可能识别单个中间体。尽管无法获得先前提出的机制的明确证据，但所有光谱证据都与它们一致。结果还强调了条件、pH、离子强度和温度对化学条件下反应性的显着影响。