Abstract

Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC₅₀ value of 34.0 μM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway.

中文翻译：

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白术根茎中两种新的倍半萜类化合物及其生物活性

摘要

分离出两种新的倍半萜，名为 selina-4(14),7,11-trien-9-ol ( 1 ) 和 selina-4(14),11-dien-7-ol ( 2 )，以及两种已知化合物来自Atractylodes macrocephala Koidz 的根茎。所有结构均根据详细的光谱分析进行分配。1的绝对构型是通过TDDFT-ECD计算建立的。发现化合物1中度抑制 LSD1 活性，IC ₅₀值为 34.0 μM。化合物1和4对 Keap1-Nrf2-ARE 通路具有调节作用。