Abstract In the present review, 182 antifouling (AF) natural products from marine microorganisms, algae and marine invertebrates reported from August 2014 to May 2020 are presented. Amongst these compounds, over half were isolated from marine-derived microorganisms, including 70 compounds from fungi and 31 compounds from bacteria. The structure–relationship of some of these compounds is also briefly discussed. Based on the work reported, a general workflow was drafted to refine the procedures for the commercialization of any novel AF compounds. Finally, butenolide, which is considered a potential environmentally friendly antifoulant, is used as a case study to show the procedures involved in AF compound work from the aspect of discovery, structure optimization, toxicity, stability, AF mechanism and coating incorporation, which highlight the current challenges and future perspectives in AF compound research.

中文翻译：

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作为防污分子的海洋天然产品——小型回顾（2014-2020）

摘要 在本综述中，介绍了 2014 年 8 月至 2020 年 5 月报告的来自海洋微生物、藻类和海洋无脊椎动物的 182 种防污 (AF) 天然产物。在这些化合物中，超过一半是从海洋微生物中分离出来的，包括来自真菌的 70 种化合物和来自细菌的 31 种化合物。还简要讨论了其中一些化合物的结构-关系。根据报告的工作，起草了一个通用工作流程，以改进任何新型 AF 化合物的商业化程序。最后，以被认为是一种潜在的环保型防污剂的丁烯内酯为例，从发现、结构优化、毒性、稳定性、AF机理和涂层掺入等方面展示了AF复合工作所涉及的程序，