This article proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between type I and type II excitability and the transition between spiking and bursting.

中文翻译：

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从生物物理到综合火力建模

本文提出了一种从任意详细的单室生物物理模型中提取低维积分和发射模型的方法。该方法旨在将生物物理模型中最大电导参数的调制与所提出的积分和发射模型中的参数调制联系起来。该方法在两个有据可查的细胞神经调节示例中进行了说明：I 型和 II 型兴奋性之间的过渡以及尖峰和爆发之间的过渡。