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Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2021-01-20 , DOI: 10.1002/jdn.10087 Hakimeh Saadati 1, 2 , Farshid Sadegzadeh 3 , Nona Sakhaie 3 , Hamdollah Panahpour 1, 2 , Mohsen Sagha 4
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2021-01-20 , DOI: 10.1002/jdn.10087 Hakimeh Saadati 1, 2 , Farshid Sadegzadeh 3 , Nona Sakhaie 3 , Hamdollah Panahpour 1, 2 , Mohsen Sagha 4
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A survey of the literature indicates that developmental disruptions in serotonin (5-HT) levels can influence brain development and function. To our knowledge, so far, there are a few studies about the effects of developmental period 5-HT depletion on cognition and behavior of adult male and female rats. Therefore, in the present study, we examined the effects of postnatal days (PND 10-20) administration of para-chlorophenylalanine (PCPA, 100mg/kg, s.c) a 5-HT synthesis inhibitor, on anxiety-related behaviors, pain sensitivity, short term recognition memory, and hippocampal and prefrontal cortex (PFC) brain-derived neurotrophic factor (BDNF) mRNA expression in adult male and female rats. Novel object recognition memory (NORM) and behavioral parameters (anxiety-like behaviors and pain sensitivity) were evaluated in early adulthood and after that, the hippocampi and PFC of the rat's brain were removed for determination of BDNF mRNA expression. Our results indicated that the postnatal period administration of PCPA impaired short term NORM. The postnatal developmental period treatment with PCPA also increased anxiety-like behaviors in the open field and elevated plus maze (EPM) tests. Postnatal PCPA treatment increased pain sensitivity in the hot plate test in both male and female rats, especially in female animals. In addition, postnatal days serotonin depletion decreased BDNF level in the hippocampus and PFC of both male and female rats. These findings demonstrate that serotonin plays the main role in neurodevelopment, cognitive functions, and behavior. Therefore serotonergic system dysregulation during the developmental periods may have more adverse influences on the brain development of rats.
中文翻译：
出生后发育期间血清素消耗导致行为和认知改变并降低大鼠大脑中的 BDNF 水平
一项文献调查表明，血清素 (5-HT) 水平的发育中断会影响大脑发育和功能。据我们所知，到目前为止，关于发育期5-HT耗竭对成年雄性和雌性大鼠认知和行为的影响的研究很少。因此，在本研究中，我们检查了出生后天数 (PND 10-20) 施用对氯苯丙氨酸 (PCPA，100mg/kg，sc) 一种 5-HT 合成抑制剂对焦虑相关行为、疼痛敏感性、短期识别记忆、海马和前额叶皮层 (PFC) 脑源性神经营养因子 (BDNF) mRNA 在成年雄性和雌性大鼠中的表达。在成年早期和之后评估新的物体识别记忆（NORM）和行为参数（焦虑样行为和疼痛敏感性），去除大鼠脑的海马和PFC用于测定BDNF mRNA表达。我们的结果表明，产后服用 PCPA 会损害短期 NORM。PCPA 的产后发育期治疗也增加了开放领域和高架十字迷宫 (EPM) 测试中的焦虑样行为。出生后 PCPA 治疗增加了雄性和雌性大鼠，尤其是雌性动物的热板试验中的疼痛敏感性。此外，出生后几天血清素耗竭降低了雄性和雌性大鼠海马和 PFC 中的 BDNF 水平。这些发现表明血清素在神经发育、认知功能和行为中起主要作用。
更新日期：2021-01-20
中文翻译：
出生后发育期间血清素消耗导致行为和认知改变并降低大鼠大脑中的 BDNF 水平
一项文献调查表明，血清素 (5-HT) 水平的发育中断会影响大脑发育和功能。据我们所知，到目前为止，关于发育期5-HT耗竭对成年雄性和雌性大鼠认知和行为的影响的研究很少。因此，在本研究中，我们检查了出生后天数 (PND 10-20) 施用对氯苯丙氨酸 (PCPA，100mg/kg，sc) 一种 5-HT 合成抑制剂对焦虑相关行为、疼痛敏感性、短期识别记忆、海马和前额叶皮层 (PFC) 脑源性神经营养因子 (BDNF) mRNA 在成年雄性和雌性大鼠中的表达。在成年早期和之后评估新的物体识别记忆（NORM）和行为参数（焦虑样行为和疼痛敏感性），去除大鼠脑的海马和PFC用于测定BDNF mRNA表达。我们的结果表明，产后服用 PCPA 会损害短期 NORM。PCPA 的产后发育期治疗也增加了开放领域和高架十字迷宫 (EPM) 测试中的焦虑样行为。出生后 PCPA 治疗增加了雄性和雌性大鼠，尤其是雌性动物的热板试验中的疼痛敏感性。此外，出生后几天血清素耗竭降低了雄性和雌性大鼠海马和 PFC 中的 BDNF 水平。这些发现表明血清素在神经发育、认知功能和行为中起主要作用。
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