Mitochondria are highly dynamic and stress-responsive organelles that are renewed, maintained and removed by a number of different mechanisms. Recent findings bring more evidence for the focused, defined, and regulatory function of the intramitochondrial proteases extending far beyond the traditional concepts of damage control and stress responses. Until recently, the macrodegradation processes, such as mitophagy, were promoted as the major regulator of OXPHOS remodelling and turnover. However, the spatiotemporal dynamics of the OXPHOS system can be greatly modulated by the intrinsic mitochondrial mechanisms acting apart from changes in the global mitochondrial dynamics. This, in turn, may substantially contribute to the shaping of the metabolic status of the cell.

线粒体是高度动态和对压力敏感的细胞器，可通过多种不同的机制进行更新，维持和去除。最近的发现为线粒体内蛋白酶的聚焦，定义和调节功能提供了更多的证据，这些功能远远超出了损伤控制和应激反应的传统概念。直到最近，诸如线粒体的宏观降解过程仍被推广为OXPHOS重塑和转换的主要调节剂。但是，OXPHOS系统的时空动力学可以通过内在的线粒体机制进行调节，而与整体线粒体动力学变化无关。反过来，这可能实质上有助于细胞代谢状态的形成。