This paper provides the current state of knowledge available from the literature regarding the use of copper sulphate (CuSO₄) in culture of freshwater and marine fish as related to toxicity, growth performance, physiology, immunity, histomorphology and antiparasitic treatment. From this review, I have assessed and discussed all of these factors, as well as the potential strategies available for use in fish farming. Acute toxicity (96h-LD₅₀) to CuSO₄ varies widely among fish species (0.001–730 mg/L) depending on various water quality factors, and many fish species are sensitive to concentrations near those required for controlling and treating parasite infections. Acute exposure to CuSO₄ may lead to mortality while sublethal exposure in different organism causes changes in feeding and swimming behaviour, growth performance, histomorphology of gills, liver, kidney, and spleen, hematology, blood biochemistry, the antioxidant defense system, and oxygen consumption. After exposure to copper sulphate, copper ions often accumulate in the gills, liver, kidney and spleen, and in the gills provokes changes in mucus and chloride cells, hyperplasia and/or hypertrophy of primary and/or secondary lamellae, edema of the gill epithelium, and lamellar fusion. Long and short-term exposure to copper sulphate may negatively affect the body growth of fish exposed, and control and treat ectoparasite infections that are discussed here. Copper sulphate may be a chemotherapeutic for controlling and treating ectoparasites in farmed fish because of its effectiveness and low cost.

本文提供了有关在淡水和海水鱼类养殖中使用硫酸铜（CuSO ₄）的毒性，生长性能，生理学，免疫性，组织形态学和抗寄生虫处理方面的文献知识。通过这次审查，我评估并讨论了所有这些因素，以及可用于鱼类养殖的潜在策略。鱼类对CuSO _4的急性毒性（96h-LD ₅₀）在不同种类（0.001-730 mg / L）中的差异很大，具体取决于各种水质因素，许多鱼类对接近控制和治疗寄生虫感染所需的浓度敏感。急性接触CuSO ₄可能会导致死亡，而不同生物体中的亚致死暴露会导致进食和游泳行为，生长性能，of，肝脏，肾脏和脾脏的组织形态，血液学，血液生化，抗氧化防御系统和耗氧量发生变化。暴露于硫酸铜后，铜离子经常积聚在腮，肝，肾和脾中，并且在腮中引起粘液和氯化物细胞变化，原发和/或继发性片状细胞增生和/或肥大，g上皮水肿。和层状融合。长期和短期接触硫酸铜可能会对暴露的鱼的身体生长产生不利影响，并控制和治疗此处讨论的外寄生虫感染。