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A Eu(III)-based Metal Organic Framework: Selective Sensing of Picric Acid and Nursing Application Values On the Cerebral Edema Induced by Cerebral Hemorrhage Via Reducing the Coagulation Factor II Activity
Journal of Fluorescence ( IF 2.6 ) Pub Date : 2021-01-05 , DOI: 10.1007/s10895-020-02667-z
Xiao-Chang Chen 1 , Feng Xi 2 , Rong Liu 2 , Jia-Wen Zhou 3
Affiliation  

A new three-dimensional lanthanide metal–organic framework (Ln-MOF), [Eu4(L)4(H2O)8]·10H2O (1, H3L = biphenyl-3′-nitro-3,4′,5-tricarboxylic acid), has been constructed via solvothermal technology and its framework has been detected by the single-crystal X-ray diffraction and elemental analyses. Complex 1 with typical emission of Eu3+ ion represents dramatic luminescence quenching affect for picric acid (PA) and the linear Stern-Volmer plot was surveyed in the consistence, ranging from 0.05 to 0.15 mM (Ksv = 98,074 M− 1). Its therapeutic effect of the compound on the cerebral edema caused by cerebral hemorrhage was estimated and the mechanism was explored. Possible binding interactions have been investigated by molecular docking simulations, from which the binding interactions are identified and the carboxyl oxygens are responsible for those identified interactions.



中文翻译:

一种基于 Eu(III) 的金属有机骨架:苦味酸的选择性感知及通过降低凝血因子 II 活性对脑出血所致脑水肿的护理应用价值

一种新的三维镧系金属有机骨架(Ln-MOF),[Eu 4 (L) 4 (H 2 O) 8 ]·10H 2 O ( 1 , H 3 L = biphenyl-3'-nitro-3, 4',5-三羧酸), 已通过溶剂热技术构建, 其骨架已通过单晶 X 射线衍射和元素分析检测到。具有典型 Eu 3+离子发射的配合物1代表了对苦味酸 (PA) 的显着发光淬灭影响,并且在一致性中调查了线性 Stern-Volmer 图,范围从 0.05 到 0.15 mM ( K sv = 98,074 M − 1)。评价了该化合物对脑出血所致脑水肿的治疗作用,并探讨了其作用机制。已经通过分子对接模拟研究了可能的结合相互作用,从中确定了结合相互作用,并且羧基氧负责那些确定的相互作用。

更新日期:2021-01-06
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