Gastric-type adenocarcinoma (GAS) of the cervix is a human papilloma virus (HPV)–independent, aggressive, and chemo-resistant adenocarcinoma. However, although the histopathological features of GAS have been extensively investigated, squamous differentiation has not been mentioned. This study aimed to elucidate the frequency of GAS with squamous differentiation and describe their clinicopathological characteristics. We retrospectively evaluated 78 patients with GAS (n = 13) and adenosquamous carcinoma (n = 65) diagnosed between 2000 and 2020. Two patients with GAS with squamous differentiation were identified. Both tumors showed advanced stage (pT2bN1) and had predominant GAS and merged squamous cell carcinoma components without p16-block positivity and HPV DNA. Gastric-type adenocarcinoma in situ was confirmed in both cases. Some cases of GAS could show squamous differentiation mimicking the usual, HPV-associated, adenosquamous carcinoma. GAS with squamous differentiation is recognized as an HPV-independent cancer.

宫颈胃型腺癌 (GAS) 是一种不依赖人乳头瘤病毒 (HPV) 的、具有侵袭性和耐药性的腺癌。然而，尽管已经广泛研究了 GAS 的组织病理学特征，但并未提及鳞状细胞分化。本研究旨在阐明具有鳞状细胞分化的 GAS 的发生频率并描述其临床病理特征。我们回顾性评估了 78 名 GAS 患者 ( n  = 13) 和腺鳞癌 ( n = 65) 在 2000 年至 2020 年间确诊。确定了两名患有鳞状细胞分化的 GAS 患者。两种肿瘤均显示晚期（pT2bN1）并且具有主要的 GAS 和合并的鳞状细胞癌成分，没有 p16 阻断阳性和 HPV DNA。两例均证实胃型原位腺癌。一些 GAS 病例可能显示鳞状分化，类似于常见的 HPV 相关腺鳞癌。具有鳞状分化的 GAS 被认为是一种不依赖于 HPV 的癌症。