Stem Cell Reviews and Reports ( IF 4.5 ) Pub Date : 2021-01-05 , DOI: 10.1007/s12015-020-10108-4 Hesam Saghaei Bagheri 1 , Mohammad Karimipour 1 , Morteza Heidarzadeh 2 , Hadi Rajabi 1 , Emel Sokullu 2, 3 , Reza Rahbarghazi 1, 4
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The COVID-19 pandemic has profoundly influenced public health and contributed to global economic divergences of unprecedented dimensions. Due to the high prevalence and mortality rates, it is then expected that the consequence and public health challenges will last for long periods. The rapid global spread of COVID-19 and lack of enough data regarding the virus pathogenicity multiplies the complexity and forced governments to react quickly against this pandemic. Stem cells represent a small fraction of cells located in different tissues. These cells play a critical role in the regeneration and restoration of injured sites. Because of their specific niche and a limited number of stem cells, the key question is whether there are different anti-viral mechanisms against viral infection notably COVID-19. Here, we aimed to highlight the intrinsic antiviral resistance in different stem cells against viral infection. These data could help us to understand the possible viral infections in different stem cells and the activation of specific molecular mechanisms upon viral entrance.
Graphical Abstract
中文翻译：
COVID-19 或其他病毒性疾病的全球爆发是否威胁到体内的干细胞库？
COVID-19 大流行对公共卫生产生了深远的影响，并导致了前所未有的全球经济分化。由于高流行率和死亡率，预计后果和公共卫生挑战将持续很长时间。COVID-19 在全球的迅速传播和缺乏足够的病毒致病性数据使复杂性成倍增加，迫使政府对这一流行病迅速做出反应。干细胞代表位于不同组织中的一小部分细胞。这些细胞在受伤部位的再生和恢复中起着关键作用。由于它们特定的生态位和有限数量的干细胞，关键问题是是否有不同的抗病毒机制来对抗病毒感染，尤其是 COVID-19。这里，我们旨在强调不同干细胞对病毒感染的内在抗病毒抗性。这些数据可以帮助我们了解不同干细胞中可能的病毒感染以及病毒进入后特定分子机制的激活。
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