Purpose

The present review article focuses on highlighting the main technologies used as tools that improve the delivery of transdermal biomolecules, addressing them from the point of view of research in the development of transdermal systems that use physical and chemical permeation enhancers and nanocarrier systems or a combination of them.

Results

Transdermal drug delivery systems have increased in importance since the late 1970s when their use was approved by the Food and Drug Administration (FDA). They appeared to be an alternative resource for the administration of many potent drugs. The first transdermal drug delivery system used for biomolecules was for the treatment of hormonal disorders. Biomolecules have been used primarily in many treatments for cancer and diabetes, vaccines, hormonal disorders, and contraception.

Conclusions

The latest technologies that have used such transdermal biomolecule transporters include electrical methods (physical penetration enhancers), some chemical penetration enhancers and nanocarriers. All of them allow the maintenance of the physical and chemical properties of the main proteins and peptides through these clinical treatments, allowing their efficient storage, transport, and release and ensuring the achievement of their target and better results in the treatment of many diseases.

Graphical abstract

中文翻译：

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生物分子透皮给药系统

目的

本综述文章重点强调用作改善透皮生物分子递送的工具的主要技术，从使用物理和化学渗透增强剂和纳米载体系统或结合使用的透皮系统开发研究的角度解决这些问题他们。

结果

自 1970 年代后期以来，透皮给药系统的重要性日益增加，当时它们的使用得到了食品和药物管理局 (FDA) 的批准。它们似乎是管理许多强效药物的替代资源。第一个用于生物分子的透皮给药系统是用于治疗激素紊乱。生物分子主要用于癌症和糖尿病、疫苗、激素紊乱和避孕的许多治疗。

结论

使用这种透皮生物分子转运蛋白的最新技术包括电学方法（物理渗透增强剂）、一些化学渗透增强剂和纳米载体。所有这些都可以通过这些临床治疗来维持主要蛋白质和多肽的物理和化学性质，使其能够有效地储存、运输和释放，并确保在许多疾病的治疗中实现其目标和更好的效果。

图形概要