We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing speed, motor skills, and attention/working memory all worsened as CRP increased but only among PWH who, on average, exhibited moderate to severe depressive symptoms (BDI-II > 22). Findings suggest that some PWH with chronically elevated depressive symptoms may have an inflammatory subtype of depression and a particular vulnerability to neurocognitive changes that may respond to drugs targeting inflammation or its neural sequelae.

我们在 143 名 HIV 感染者 (PWH) 的队列中研究了抑郁症状（贝克抑郁量表-II (BDI-II)）和全身炎症（血浆 C 反应蛋白 (CRP)）对神经认知纵向特征的联合影响。抗逆转录病毒治疗。随着 CRP 升高，整体神经认知、处理速度、运动技能和注意力/工作记忆均恶化，但仅限于平均表现出中度至重度抑郁症状的感染者 (BDI-II > 22)。研究结果表明，一些患有慢性抑郁症状的感染者可能患有抑郁症的炎症亚型，并且特别容易发生神经认知变化，这些变化可能会对针对炎症或其神经后遗症的药物产生反应。