Influenza is a potential cause of severe disease in the immunocompromised. Patients with hypogammaglobulinemia, in spite of adequate replacement therapy, are at risk of significant morbidity and adverse outcomes. A seasonal vaccine is the primary prophylactic countermeasure to limit disease. The aim of this study was to evaluate the attitude, knowledge, and influenza vaccine uptake among Irish patients receiving immunoglobulin replacement therapy (IgRT), as well as uptake in co-habitants. Fifty-seven percent of patients receiving IgRT at a regional immunology referral center completed a questionnaire evaluation. Seventy-six percent of IgRT patients received the influenza vaccine for the 2019 season. Ninety-eight percent recognized that influenza could be prevented with vaccination, and 81% deemed it a safe treatment. Ninety-three percent correctly identified that having a chronic medical condition, independent of age, was an indication for vaccination. Despite excellent compliance and knowledge, many were not aware that vaccination was recommended for co-habitants, and only 24% had full vaccine coverage at home. Those who received advice regarding vaccination of household members had higher rates of uptake at home. This study demonstrates awareness and adherence to seasonal influenza vaccine recommendations among patients receiving IgRT. Over three quarters felt adequately informed, the majority stating physicians as their information source. We identified an easily modifiable knowledge gap regarding vaccination of household members. This data reveals a need to emphasize the importance of vaccination for close contacts of at-risk patients, to maintain optimal immunity and health outcome.

流感是免疫功能低下者严重疾病的潜在原因。尽管有足够的替代治疗，低丙种球蛋白血症患者仍存在显着发病率和不良后果的风险。季节性疫苗是限制疾病的主要预防措施。本研究的目的是评估接受免疫球蛋白替代疗法 (IgRT) 的爱尔兰患者的态度、知识和流感疫苗摄取情况，以及同居者的摄取情况。在区域免疫学转诊中心接受 IgRT 的患者中有 57% 完成了问卷评估。76% 的 IgRT 患者在 2019 年接种了流感疫苗。98% 的人认为可以通过接种疫苗来预防流感，81% 的人认为这是一种安全的治疗方法。93% 的人正确识别出患有慢性疾病（与年龄无关）是接种疫苗的指征。尽管有出色的依从性和知识，但许多人并不知道建议同居者接种疫苗，只有 24% 的人在家中进行了全面的疫苗接种。接受家庭成员疫苗接种建议的人在家中接种率较高。本研究表明接受 IgRT 的患者对季节性流感疫苗建议的认识和依从性。超过四分之三的受访者认为信息充分，大多数人将医生作为他们的信息来源。我们发现了一个容易改变的关于家庭成员疫苗接种的知识差距。这些数据表明有必要强调对高危患者的密切接触者进行疫苗接种的重要性，