Purpose

This review aims to summarize the key findings of several miRNAs and their roles in polycystic ovary syndrome with insulin resistance, characterize the disease pathogenesis, and establish a new theoretical basis for diagnosing, treating, and preventing polycystic ovary syndrome.

Methods

Relevant scientific literature was covered from 1992 to 2020 by searching the PubMed database with search terms: insulin/insulin resistance, polycystic ovary syndrome, microRNAs, and metabolic diseases. References of relevant studies were cross-checked.

Results

The related miRNAs (including differentially expressed miRNAs) and their roles in pathogenesis, and possible therapeutic targets and pathways, are discussed, highlighting controversies and offering thoughts for future directions.

Conclusion

We found abundant evidence on the role of differentially expressed miRNAs with its related phenotypes in PCOS. Considering the essential role of insulin resistance in the pathogenesis of PCOS, the alterations of associated miRNAs need more research attention. We speculate that race/ethnicity or PCOS phenotype and differences in methodological differences might lead to inconsistencies in research findings; thus, several miRNA profiles need to be investigated further to qualify for the potential therapeutic targets for PCOS-IR.

中文翻译：

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miRNA 在多囊卵巢综合征伴胰岛素抵抗中的作用

 目的

本文旨在总结几种miRNA的主要发现及其在胰岛素抵抗多囊卵巢综合征中的作用，阐明疾病的发病机制，为多囊卵巢综合征的诊断、治疗和预防建立新的理论基础。

 方法

通过使用以下搜索词搜索 PubMed 数据库，涵盖了 1992 年至 2020 年的相关科学文献：胰岛素/胰岛素抵抗、多囊卵巢综合征、microRNA 和代谢疾病。交叉检查了相关研究的参考文献。

 结果

讨论了相关的 miRNA（包括差异表达的 miRNA）及其在发病机制中的作用，以及可能的治疗靶点和途径，强调了争议并为未来的方向提供了思考。

 结论

我们发现了大量证据证明差异表达的 miRNA 及其相关表型在 PCOS 中的作用。考虑到胰岛素抵抗在 PCOS 发病机制中的重要作用，相关 miRNA 的改变需要更多的研究关注。我们推测，种族/族裔或 PCOS 表型以及方法学差异可能会导致研究结果的不一致；因此，需要进一步研究几个 miRNA 谱，以确定 PCOS-IR 的潜在治疗靶点。