Cellulose nanocrystals (CNC) possess many advanced applications such as enzyme immobilization, synthesis of antimicrobial drugs, and drug carriers in therapeutic and diagnostic medicine due to its mechanical, liquid crystalline nature and rheological properties. The present study focuses on the usage of cellulose nanocrystals extracted from organic waste biorefineries like orange and lychee peels, as a drug transporter for the tetracycline antibiotic drug. Since cellulose nanocrystals are nontoxic, they could be used as a potential drug transporter for tetracycline. CNC was obtained from natural products following steps like delignification, bleaching, and hydrolysis of cellulose part of orange and lychee peels. To characterize the extracted CNC, from the fruit peels of orange and lychee, TGA, DSC, SEM, and FTIR analyses were carried out. The acidic pH around 2.0 was maintained for drug adsorption procedures of tetracycline uptake by CNC. Langmuir, Freundlich, Temkin, and Dubinin isotherms were employed to fit the adsorption experimental data, qmax = 139.6 mg/g and 179.1 mg/g for orange and lychee peel-extracted CNC respectively. The in vitro discharge of tetracycline from CNC was supported in phosphoric buffer medium at a pH of 7.2. The maximum tetracycline release was 67.41% for orange peel and 73.19% for lychee peel respectively within a period of 72 h. Thus, the procedure of tetracycline adsorption and desorption from cellulose nanocrystals confirms to be safe without exhibiting any harmful impacts on health.

纤维素纳米晶体（CNC）由于其机械，液晶性质和流变性质，在酶和固定剂，抗菌药物的合成以及治疗和诊断药物中的药物载体等方面具有许多先进的应用。本研究的重点是从有机废料生物提炼厂（如橙皮和荔枝皮）中提取的纤维素纳米晶体作为四环素抗生素药物的转运蛋白。由于纤维素纳米晶体无毒，因此可以用作四环素的潜在药物转运蛋白。CNC是从天然产物中按照以下步骤获得的：脱木素，漂白，橙皮和荔枝皮的纤维素部分水解。为了表征提取的CNC，从橙皮和荔枝的果皮中进行了TGA，DSC，SEM和FTIR分析。通过CNC吸收四环素的药物吸附程序，可保持2.0左右的酸性pH。Langmuir，Freundlich，Temkin和Dubinin等温线用于拟合吸附实验数据，橙皮和荔枝皮提取的CNC的qmax分别为139.6 mg / g和179.1 mg / g。在pH值为7.2的磷酸缓冲液中支持从CNC体外排出四环素。在72小时内，橙皮和荔枝皮的最大四环素释放量分别为67.41％和73.19％。因此，四环素从纤维素纳米晶体吸附和解吸的过程证实是安全的，不会对健康产生任何有害影响。用杜宾宁等温线拟合吸附实验数据，橙皮和荔枝皮提取的CNC的qmax分别为139.6 mg / g和179.1 mg / g。在pH值为7.2的磷酸缓冲液中支持从CNC体外排出四环素。在72小时内，橙皮和荔枝皮的最大四环素释放量分别为67.41％和73.19％。因此，四环素从纤维素纳米晶体吸附和解吸的过程证实是安全的，不会对健康产生任何有害影响。用杜宾宁等温线拟合吸附实验数据，橙皮和荔枝皮提取的CNC的qmax分别为139.6 mg / g和179.1 mg / g。在pH值为7.2的磷酸缓冲液中支持从CNC体外排出四环素。在72小时内，橙皮和荔枝皮的最大四环素释放量分别为67.41％和73.19％。因此，四环素从纤维素纳米晶体吸附和解吸的过程证实是安全的，不会对健康产生任何有害影响。荔枝皮在72小时内分别占19％。因此，四环素从纤维素纳米晶体吸附和解吸的过程证实是安全的，不会对健康产生任何有害影响。荔枝皮在72小时内分别占19％。因此，四环素从纤维素纳米晶体吸附和解吸的过程证实是安全的，不会对健康产生任何有害影响。