Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual's lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health. Cite this article: Bone Joint Res 2020;9(10):709-718.

中文翻译：

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骨矿物质作为药物寻找部分和废物场。


骨骼是一种动态组织，四分之一的小梁骨和五分之一的皮质骨每年都会在一个持续整个个体一生的复杂过程中不断更换。骨在矿物质的稳态中具有重要作用，非化学计量的羟基磷灰石骨矿物质形成骨的无机相。由于其晶体结构和化学性质，羟基磷灰石 (HA) 和相关磷灰石具有卓越的分子结合能力。这篇评论文章从历史角度描述了骨矿物质中微量元素的积累。植入的合成来源的透明质酸颗粒已被证明是系统循环药物的有效募集部分，可以对材料进行局部生物调节并产生治疗效果。然而，骨矿物质和磷灰石也充当微量元素和药物的废物堆，严重影响环境和人类健康。引用本文：骨关节研究2020;9(10):709-718。