Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor,RSC Chemical Biology

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Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2021-1-5 , DOI: 10.1039/d0cb00204f
Kaho Suzuki ₁ , Yousuke Takaoka ₁ , Minoru Ueda _{1,

2}

Affiliation

We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.

中文翻译：

抑制植物转录因子蛋白质-蛋白质相互作用的钉合 JAZ9 肽的合理设计

我们在此描述了用于茉莉酸相关转录因子的订书肽抑制剂的开发。设计的肽选择性抑制 MYCs，茉莉酸信号传导的主调节剂，并选择性抑制拟南芥中MYC 介导的基因表达。它被提议作为一种用于分析 MYC 相关 jasmoante 信号的新型化学工具。

更新日期：2021-01-05

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