CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits.

中文翻译：

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有条件敲除兴奋性神经元中的转录因子 CTCF 会导致认知缺陷


CCCTC 结合因子 (CTCF) 是一种参与组织染色质结构的转录因子。已知 CTCF 表达的减少会产生不同的临床特征。此外，条件敲除（cKO）研究显示，CTCF cKO 小鼠的兴奋性神经元中星形胶质细胞和小胶质细胞发生反应性神经胶质增生，随后出现年龄依赖性细胞死亡。为了评估 20 周以上 CTCF cKO 小鼠的认知能力，我们使用触摸屏设备检查了成对辨别 (PD)、PD 逆转学习 (PDr) 和不同的配对关联学习 (dPAL) 任务。我们在 dPAL 触摸屏测试中发现认知障碍，表明长期 Ctcf 基因缺陷会导致认知缺陷。