Abstract: The upper aerodigestive tract (UAT) is the first line of defense against environmental stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular junctions, epithelial cells, and immune cells are the major constituents of this defensive mucosal barrier. Laryngopharyngeal reflux (LPR) is recognized as an independent risk factor for UAT mucosal disorders, and in this review, we describe the components and functions of the mucosal barrier and the results of LPR-induced mucosal inflammation in the UAT. We discuss the interactions between the refluxate and the mucosal components and the mechanisms through which these damaging events disrupt and alter the mucosal barriers. In addition, we discuss the dynamic alterations in the mucosal barrier that might be potential therapeutic targets for LPR-induced disorders.

Keywords: laryngopharyngeal reflux, LPR, upper aerodigestive tract, UAT, inflammatory response, mucosal barrier dysfunction


中文翻译：

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上咽消化道粘膜屏障功能障碍的喉咽反流和炎症反应

摘要：上呼吸消化道（UAT）是抵抗环境压力（如抗原，微生物，吸入剂，食物等）的第一道防线，粘蛋白，细胞内连接，上皮细胞和免疫细胞是这种防御性粘膜屏障的主要成分。喉咽反流（LPR）被认为是UAT粘膜疾病的独立危险因素，在本综述中，我们描述了粘膜屏障的成分和功能以及LAT引起的UAT粘膜炎症的结果。我们讨论了回流与粘膜成分之间的相互作用以及这些破坏性事件破坏和改变粘膜屏障的机制。此外，我们讨论了粘膜屏障的动态改变，这可能是LPR诱发疾病的潜在治疗靶标。

关键词：喉咽反流LLP上消化道UAT炎症反应黏膜屏障功能障碍