Objective: The aim of our study was to systematically evaluate the prognostic effects of various circrnas and to explore the prognostic value of circRNA in breast cancer patients. Methods: A systematical search was conducted on PubMed, Scopus, EMBASE, and the Cochrane Library databases. Eligible studies reporting on the association among circRNAs and prognostic values of breast cancer patients were included. Fixed-effects and random effects models were used to calculate the pooled hazard ratio values of overall survival and disease free survival. In addition, funnel plots were used to qualitatively analyze the publication bias. Results:28 studies were included in our meta-analysis. The pooled hazard ratio values of overall survival and disease free survival related to different circRNAs expression in breast cancer patients were 1.68 (1.44-1.97), 2.63 (1.95-3.53).We have identified a total of 28 circRNAs including 19 significantly up-regulated expression circRNAs and 9 significantly down-regulated expression circRNAs in BC(breast cancer) patients. Moreover, all of them revealed mechanisms and have the function of promoting or inhibiting the proliferation, metastasis or invasion of breast cancer cells by acting on the corresponding target. Conclusion: Overall, specific circRNAs are significantly associated with the prognosis of BC patients and potentially eligible for the prediction of patients survival. It also provides a potential value for clinical decision-making development and may serve as a promising circRNAs-based target therapy waiting for further elucidation.

中文翻译：

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乳腺癌患者circRNA表达的预后意义：一项荟萃分析

目的：本研究的目的是系统评估各种马戏团的预后效果，并探讨circRNA在乳腺癌患者中的预后价值。方法：对PubMed，Scopus，EMBASE和Cochrane图书馆数据库进行系统搜索。纳入了关于circRNA与乳腺癌患者预后价值之间相关性的合格研究报告。使用固定效应和随机效应模型来计算总体存活率和无病存活率的合并危险比值。此外，使用漏斗图定性分析出版物的偏倚。结果：28项研究被纳入我们的荟萃分析。与不同circRNA表达相关的乳腺癌患者总生存期和无疾病生存期的风险比合计值为1.68（1.44-1.97），2。63（1.95-3.53）。我们已经鉴定出总共28个circRNA，其中包括19个在BC（乳腺癌）患者中表达的circRNAs和9个显着下调的circRNAs。而且，它们都揭示了作用机理，并具有通过作用于相应靶标来促进或抑制乳腺癌细胞的增殖，转移或侵袭的功能。结论：总的来说，特异性circRNA与BC患者的预后显着相关，并且可能符合患者生存的预测。它还为临床决策制定提供了潜在价值，并可作为有希望的基于circRNA的靶标治疗方法，等待进一步阐明。我们已经鉴定出总共28种circRNA，其中包括BC（乳腺癌）患者的19种表达circRNA和9种显着下调circRNA。而且，它们都揭示了作用机理，并具有通过作用于相应靶标来促进或抑制乳腺癌细胞的增殖，转移或侵袭的功能。结论：总的来说，特异性circRNA与BC患者的预后显着相关，并且可能符合患者生存的预测。它还为临床决策制定提供了潜在价值，并可作为有希望的基于circRNA的靶标治疗方法，等待进一步阐明。我们已经鉴定出总共28种circRNA，其中包括BC（乳腺癌）患者的19种表达circRNA和9种显着下调circRNA。而且，它们都揭示了作用机理，并具有通过作用于相应靶标来促进或抑制乳腺癌细胞的增殖，转移或侵袭的功能。结论：总的来说，特异性circRNA与BC患者的预后显着相关，并且可能符合患者生存的预测。它还为临床决策制定提供了潜在价值，并可作为有希望的基于circRNA的靶标治疗方法，等待进一步阐明。它们都揭示了机制，并具有通过作用于相应靶标来促进或抑制乳腺癌细胞的增殖，转移或侵袭的功能。结论：总的来说，特异性circRNA与BC患者的预后显着相关，并且可能符合患者生存的预测。它还为临床决策制定提供了潜在价值，并可作为有希望的基于circRNA的靶标治疗方法，等待进一步阐明。它们都揭示了机制，并具有通过作用于相应靶标来促进或抑制乳腺癌细胞的增殖，转移或侵袭的功能。结论：总的来说，特异性circRNA与BC患者的预后显着相关，并且可能符合患者生存的预测。它还为临床决策制定提供了潜在价值，并可作为有希望的基于circRNA的靶标治疗方法，等待进一步阐明。