Neurological disorders (NLDs) are among the top leading causes for disability worldwide. Dramatic changes in the epigenetic topography of the brain and nervous system have been found in many NLDs. Histone lysine acetylation has prevailed as one of the well characterised epigenetic modifications in these diseases. Two instrumental components of the acetylation machinery are the evolutionarily conserved Bromodomain and PHD finger containing (BRPF) and Bromo and Extra terminal domain (BET) family of proteins, also referred to as acetylation ‘readers’. Several reasons, including their distinct mechanisms of modulation of gene expression and their property of being highly tractable small molecule targets, have increased their translational relevance. Thus, compounds which demonstrated promising results in targeting these proteins have advanced to clinical trials. They have been established as key role players in pathologies of cancer, cardiac diseases, renal diseases and rheumatic diseases. In addition, studies implicating the role of these bromodomains in NLDs are gaining pace. In this review, we highlight the findings of these studies, and reason for the plausible roles of all BET and BRPF members in NLDs. A comprehensive understanding of their multifaceted functions would be radical in the development of therapeutic interventions.

中文翻译：

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BET 和 BRPF 溴结构域在神经系统疾病中的 BRD (BiRD) 视图

神经系统疾病 (NLD) 是全球导致残疾的主要原因之一。在许多 NLD 中发现了大脑和神经系统表观遗传学的显着变化。组蛋白赖氨酸乙酰化已成为这些疾病中表征良好的表观遗传修饰之一。乙酰化机制的两个重要组成部分是进化上保守的含溴结构域和 PHD 指 (BRPF) 和溴和额外末端结构域 (BET) 蛋白质家族，也称为乙酰化“阅读器”。几个原因，包括它们独特的基因表达调节机制和它们作为高度易处理的小分子靶标的特性，增加了它们的翻译相关性。因此，在靶向这些蛋白质方面显示出有希望的结果的化合物已进入临床试验。它们已被确立为癌症、心脏病、肾病和风湿病病理学中的关键角色。此外，有关这些溴结构域在 NLD 中的作用的研究正在加快步伐。在这篇综述中，我们强调了这些研究的结果，以及所有 BET 和 BRPF 成员在 NLD 中的合理作用的原因。全面了解它们的多方面功能对于治疗干预措施的发展至关重要。我们强调了这些研究的结果，以及所有 BET 和 BRPF 成员在 NLD 中的合理作用的原因。全面了解它们的多方面功能对于治疗干预措施的发展至关重要。我们强调了这些研究的结果，以及所有 BET 和 BRPF 成员在 NLD 中的合理作用的原因。全面了解它们的多方面功能对于治疗干预措施的发展至关重要。