Amino acids and acylcarnitines play an important role as substrates and intermediate products in most of pathways involved in schizophrenia development such as mitochondrial dysfunction, inflammation, lipid oxidation, DNA damage, oxidative stress, and apoptosis. It seems relevant to use an integrated approach with ‘omics’ technology to study their contribution. The aim of our study was to investigate serum amino acid and acylcarnitine levels in antipsychotics-treated patients with chronic schizophrenia compared with healthy donors. We measured serum levels of 15 amino acids and 30 acylcarnitines in 37 patients with schizophrenia and 36 healthy donors by means of tandem mass spectrometry. In summary, patients with chronic schizophrenia had an altered concentration of a few amino acids and acylcarnitines in comparison to the healthy probands. Further research is needed to assess and understand the identified changes.

中文翻译：

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慢性精神分裂症患者的氨基酸和酰基肉碱水平：初步研究

氨基酸和酰基肉碱在精神分裂症发展的大多数途径（例如线粒体功能障碍，炎症，脂质氧化，DNA损伤，氧化应激和凋亡）中作为底物和中间产物起着重要作用。用“组学”技术集成方法来研究其贡献似乎很重要。我们研究的目的是调查与健康供体相比，抗精神病药治疗的慢性精神分裂症患者的血清氨基酸和酰基肉碱水平。我们通过串联质谱法测量了37位精神分裂症患者和36位健康供体的血清中15种氨基酸和30种酰基肉碱的水平。总之，与健康的先证者相比，慢性精神分裂症患者的某些氨基酸和酰基肉碱的浓度发生了变化。