Abstract

Two new cobalt(II) coordination polymers based on H₄bpta (H₄bpta = 3,3′,5,5′-biphenyltetracarboxylic acid) and N-donor ligands, namely [Co₂(1,3-bimb)₂(bpta)]_n·2nH₂O (1) and [Co₂(1,4-bib)₂(bpta)]_n·2n(H₂O·DMF) (2), (1,4-bib = 1,4-bis(imidazol-1-yl)benzene, 1,3-bimb = 1,3-bis((1H-imidazol-1-yl)methyl)benzene), have been obtained under solvothermal conditions. Series of biological experiments were performed for the biological activity evaluation. Firstly, the western blotting assay was performed to evaluate the inflammasome activation in the endothelial cells of retina after compound treatment. Besides, the enzyme linked immunosorbent assay (ELISA) detection kit was used to measure the down-stream production of the inflammasome activation.

摘要

两种基于 H ₄ bpta（H ₄ bpta = 3,3',5,5'-联苯四甲酸）和 N-供体配体的新型钴 (II) 配位聚合物，即 [Co ₂ (1,3-bimb) ₂ ( bpta)] _n ·2 n H ₂ O ( 1 ) 和 [Co ₂ (1,4-bib) ₂ (bpta)] _n ·2 n (H ₂ O·DMF) ( 2 ), (1,4-bib = 1,4-双（咪唑-1-基）苯，1,3-bimb = 1,3-双（（1 H-咪唑-1-基)甲基)苯)，已在溶剂热条件下获得。进行了一系列生物学实验以进行生物学活性评价。首先，进行蛋白质印迹试验以评估复合治疗后视网膜内皮细胞中炎性体的激活。此外，酶联免疫吸附试验（ELISA）检测试剂盒用于测量炎症小体活化的下游产生。