Abstract

This study evaluated the association of urinary nitrate concentrations with cognition in older subjects enrolled in the NHANES study. We also explored whether associations between urinary nitrate and cognition were modified by cardiovascular risk, vitamin D status and vitamin C intake. Two NHANES cycles were merged (2011–2012 and 2013–2014) and a total of 1,015 adults aged 60–80 (69.4 ± 0.3) years were included. Cognition was assessed using the Word List Learning, Word List Recall, Animal Fluency and the Digit Symbol Substitution tests. Urinary nitrate was analysed using electrospray tandem mass spectrometry. Urinary nitrate concentrations were not associated with cognitive performance on any of the cognitive tests. Associations were also not significant in subjects at greater risk for cognitive impairment (i.e. high cardiovascular risk and non-optimal vitamin D status). Longitudinal analyses are needed to explore the associations of urinary nitrate concentrations with dietary nitrate intake and cognitive function.

摘要

本研究评估了参加 NHANES 研究的老年受试者的尿硝酸盐浓度与认知能力的关联。我们还探讨了尿硝酸盐与认知之间的关联是否会因心血管风险、维生素 D 状态和维生素 C 摄入量而改变。合并了两个 NHANES 周期（2011-2012 和 2013-2014），总共包括 1,015 名 60-80 (69.4 ± 0.3) 岁的成年人。使用单词列表学习、单词列表回忆、动物流畅性和数字符号替换测试评估认知。使用电喷雾串联质谱法分析尿硝酸盐。在任何认知测试中，尿液硝酸盐浓度与认知能力无关。在认知障碍风险较高的受试者中，关联也不显着（即 高心血管风险和非最佳维生素 D 状态）。需要纵向分析来探索尿硝酸盐浓度与膳食硝酸盐摄入量和认知功能的关联。