ABSTRACT

The mole fraction solubility of sulphadiazine (SD) in {Carbitol® (1) + water (2)} binary solvent mixtures at different temperatures from (278.15 to 313.15) K was determined. Solubility values were correlated with the combined nearly ideal binary solvent/Redlich-Kister, modified Wilson and Jouyban-Acree models. Preferential solvation parameters of SD by Carbitol® (δx_1,3) were derived from their thermodynamic solution properties using the inverse Kirkwood-Buff integrals method. δx_1,3 values are negative in water-rich mixtures but positive in Carbitol® mole fractions higher than 0.12. In the former case is conjecturable that hydrophobic hydration around non-polar groups of SD plays a relevant role in drug solvation.

摘要

测定了磺胺嘧啶 (SD) 在 {Carbitol® (1) + 水 (2)} 二元溶剂混合物中在 (278.15 至 313.15) K 的不同温度下的摩尔分数溶解度。溶解度值与组合近乎理想的二元溶剂/Redlich-Kister、改良的Wilson 和Jouyban-Acree 模型相关。Carbitol® ( δx _1,3 )的 SD 的优先溶剂化参数是使用逆柯克伍德-布夫积分法从它们的热力学溶液性质推导出来的。δx _1,3值在富水混合物中为负值，但在 Carbitol® 摩尔分数高于 0.12 时为正值。在前一种情况下，可以推测 SD 非极性基团周围的疏水性水合在药物溶剂化中起相关作用。