Porcine endogenous retroviruses (PERVs) -A and -B are integrated in the genome of all pigs, whereas PERV-C is found in many, but not all pigs. Some immortalized pig cell lines, among them lymphoma cells, but also mitogen activated primary lymphocytes have been shown to release virus particles, which were able to infect human cells and some of them were recombinant PERV-A/C. Since retroviruses can induce lymphomas, two newly established pig lymphoma cell lines and an older one (L23) were analysed for PERV expression. All three lines harboured PERV-A, PERV-B and PERV-C proviruses, but PERV-A/C recombinants were found only in the genome of L23 cells. The expression at the RNA level was very low and no protein expression and particle release was observed, suggesting that PERVs were not involved in the pathogenesis of these lymphomas. However, all three cell lines were infected with the porcine lymphotropic herpesvirus-3 (PLHV-3), which may have been involved in lymphoma development.

猪内源性逆转录病毒 (PERVs) -A 和 -B 整合在所有猪的基因组中，而 PERV-C 存在于许多猪中，但不是所有猪。一些永生化的猪细胞系，其中包括淋巴瘤细胞，以及有丝分裂原活化的原代淋巴细胞，已被证明可以释放病毒颗粒，这些病毒颗粒能够感染人类细胞，其中一些是重组的 PERV-A/C。由于逆转录病毒可以诱导淋巴瘤，因此分析了两种新建立的猪淋巴瘤细胞系和一种较老的细胞系 (L23) 的 PERV 表达。所有三个系都含有 PERV-A、PERV-B 和 PERV-C 前病毒，但仅在 L23 细胞的基因组中发现了 PERV-A/C 重组体。RNA 水平的表达非常低，没有观察到蛋白质表达和颗粒释放，表明 PERV 不参与这些淋巴瘤的发病机制。然而，